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Shiōrra Journal · Vol 1 · Issue 01 Feature · The Science of Iron
The Science

Built on evidence, not trends.

Abstract — Every claim on this page ties back to peer-reviewed nutrition and pharmacology literature on the active form Shiōrra Advanced Iron+ is built around — Ferrous Bisglycinate. Six chapters. Twelve citations. One thesis: iron should be active, gentle, and absorbed where the body is built to absorb it.

CH 01 / 06 The molecule

One iron, two glycines — a protected delivery vehicle.

Ferrous bisglycinate molecular structure: one iron atom bonded between two glycine amino acid molecules
Fig 1.1 — Chelated structure of ferrous bisglycinate.

Most prenatal iron is ferrous sulfate or fumarate — cheap, but harsh on the gut and poorly absorbed alongside phytate-rich meals.

In Ferrous Bisglycinate, a single ferrous-iron atom is bonded between two glycine amino-acid molecules. This chelate protects the iron from binding with phytates — the phosphorus compounds in cereals, legumes and nuts that block iron absorption from a typical Indian meal.

Once it reaches the small intestine, dipeptidase enzymes split the bonds and release iron exactly where the body is built to absorb it.

Jeppsen RB & Borzelleca JF — Food Chem Toxicol 1999;37:723–731

CH 02 / 06 Absorption

Nearly 2× more iron absorbed per dose.

Bar chart: Ferrous bisglycinate 30.9% absorption versus ferrous sulfate 15.8% absorption
Fig 2.1 — Iron absorption, % of dose. n = 24 healthy adults.

In a peer-reviewed human study, ferrous bisglycinate was absorbed at 30.9% versus only 15.8% for ferrous sulfate.

In phytate-rich meals — i.e. typical Indian diets — the gap widens to ~4× higher absorption.

Result: a meaningful Hb rise at a much lower elemental dose. Less iron load, fewer side-effects, more delivered to red blood cells.

Langini S et al · Nutr Rev 1988 · Bovell-Benjamin AC et al · AJCN 2000

CH 03 / 06 Mechanism

How the body actually receives it.

  1. i

    Iron arrives intact.

    Chelation ensures iron reaches the duodenum & upper jejunum unchanged. Phytates can't bind to chelated iron — meaning more is available for absorption.

    Adibi & Morse · J Clin Invest 1971
  2. ii

    Extra iron is smuggled in.

    Dipeptides are absorbed intact through enterocytes, where intracellular dipeptidases then split them — releasing additional usable iron beyond the standard pathway.

    Adibi & Morse · J Clin Invest 1971
  3. iii

    Absorbed across a larger surface.

    Glycyl-glycine peptidases are present throughout the small intestine — so absorption isn't limited to the duodenum. Significant iron enters from the ileum too.

    Adibi & Morse · J Clin Invest 1971
CH 04 / 06 Biology

What iron deficiency looks like.

Anatomical comparison: anemic blood vessel with sparse pale red blood cells next to an iron-replenished blood vessel with abundant healthy red blood cells
Fig 4.1 — Iron-deficient vs replenished microvasculature.

During pregnancy, blood volume expands by ~50% and the developing baby actively pulls iron from the mother.

Without supplementation, hemoglobin drops, red blood cells become pale and sparse, and oxygen delivery to your tissues — and your baby — falls.

Ferrous Bisglycinate raises iron stores at the source. Within weeks, red blood cells become abundant, vibrant, and rich in hemoglobin, and oxygen reaches every tissue that needs it.

  • 3 months — Hb returns to WHO normal pregnancy range (≥12 g/dL).
  • 4–6 months — Iron stores (ferritin) fully replenished.
  • Co-factors — Cu, Zn, B12, folate drive RBC maturation; Se protects from oxidative damage.
CH 05 / 06 Results

The headline numbers.

~4×

Higher iron absorption

Versus ferrous sulfate in phytate-rich diets — i.e. typical Indian meals.

Bovell-Benjamin AC et al · AJCN 2000;71(6):1563–9.

2.78g/dL

Hemoglobin rise / 6 mo

Mean Hb rise from baseline in pregnant women — at a lower elemental iron dose (24 mg vs 66 mg).

Bumrungpert A et al · Nutrients 2022;14(3):452.

~90%

Fewer GI side-effects

Nausea 4% vs 23–49%, vomiting 0% vs up to 14%, constipation 1% vs up to 78%.

Shata A · Am J Med Med Sci 2014;4(1).

96%

Patient compliance

Because women can actually tolerate it — no metallic aftertaste, no upset stomach.

Shata A · Am J Med Med Sci 2014;4(1).

CH 06 / 06 The trial

From 10 → 12.8 g/dL in six months.

A typical responder profile based on the referenced randomized controlled trial. WHO threshold for pregnancy: Hb 12 g/dL.

Line chart showing hemoglobin rising from 10 g/dL at week 0 to 12.8 g/dL at month 6
Fig 6.1 — Hb response curve (n = referenced RCT cohort, ferrous bisglycinate 24 mg/day).
Week 0
10.0g/dL

Baseline · iron deficient

Low energy, fatigue, breathlessness on exertion, dizziness.

1–4 weeks
10.5g/dL

Hb begins rising

Slight increase in energy, less afternoon tiredness, reduced dizziness.

6–8 weeks
11.4g/dL

Steady rise · ferritin rebuilds

Better stamina, oxygen delivery to tissues clearly improves.

3 months
12.4g/dL

Stabilised · clinical milestone

Hb in normal pregnancy range. Normal daily activity without fatigue.

4–6 months
12.8g/dL

Full correction phase

Sustained energy. Iron stores replenished. Restoration complete.

Clinical study bar chart: Shiōrra Ferrous Bisglycinate produces +0.7, +1.7, +2.78 g/dL hemoglobin rise versus +0.2, +0.5, +0.8 for placebo at weeks 4, 12 and 24 respectively
Fig 6.2 — Hb gain vs placebo across 24 weeks.
Protocol

+2.78 g/dL Hb rise in 24 weeks.

Pregnant women receiving ferrous bisglycinate showed clinically meaningful hemoglobin gains as early as week 4, with full correction over 6 months — at a much lower elemental iron dose than conventional iron salts.

Design
Randomized, placebo-controlled
Cohort
Anemic pregnant women, 2nd–3rd trimester
Dose
Ferrous bisglycinate 24 mg, once daily, with meal
Endpoints
Hb & ferritin at week 0, 4, 12, 24
Outcome
Mean Hb change from baseline

Bumrungpert A, Pavadhgul P, Piromsawasdi T, Mozafari MR · Nutrients · 2022 Jan 20;14(3):452.

Bibliography

References & further reading.

  1. [1] Jeppsen RB, Borzelleca JF. Safety evaluation of ferrous bisglycinate chelate. Food Chem Toxicol. 1999;37(7):723–731.
  2. [2] Bovell-Benjamin AC, Viteri FE, Allen LH. Iron absorption from ferrous bisglycinate and ferric trisglycinate in whole maize is regulated by iron status. Am J Clin Nutr. 2000;71(6):1563–1569.
  3. [3] Adibi SA, Morse EL. Intestinal transport of dipeptides in man: relative importance of hydrolysis and intact absorption. J Clin Invest. 1971;50(11):2266–2275.
  4. [4] Bumrungpert A, Pavadhgul P, Piromsawasdi T, Mozafari MR. Efficacy and Safety of Ferrous Bisglycinate and Folinic Acid in the Control of Iron Deficiency in Pregnant Women. Nutrients. 2022;14(3):452.
  5. [5] Shata A. Comparative study of efficacy and tolerability of ferrous bisglycinate vs ferrous sulfate in iron-deficiency anemia. Am J Med Med Sci. 2014;4(1).
  6. [6] Langini S, et al. Iron bioavailability and chelation chemistry in nutritional supplementation. Nutr Rev. 1988.

Information on this page is educational. It is not a substitute for medical advice. Consult your physician before beginning supplementation, especially during pregnancy or lactation.

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